CURCUMIN EXTRACTION UNIT

Curcumin (diferuloyl methane), the natural yellow pigment in turmeric, is isolated from the rhizomes of the plant Curcuma longa. It constitutes about 3-4% of the composition of turmeric. In the south and southeast tropical Asian countries, turmeric has been used for centuries as a spice to give the specific flavor and yellow color to curry. Turmeric became a very important spice to mankind when it was observed that the addition of turmeric powder in food preparation preserved its freshness and nutritive value.

Turmeric, as an additive, improved the palatability. Aesthetic appeal and shelf life of perishable food items. The use of turmeric became more popular when it was found to act as a therapeutic agent for various illnesses. In the Ayurvedic system of medicine, turmeric is used as a tonic and as a blood purifier. Its role in the treatment of skin diseases and its ability to soften rough skin resulted in the prolific use of turmeric in topical creams and bath soaps in India. Turmeric is also used in home remedies in the treatment of cuts, wounds, bruises, and sprains. Its use as an anti-inflammatory and antimicrobial agent has been recognized for more than a century.

The importance of turmeric in medicine took a new twist when it was discovered that the dried rhizome of Curcuma longa is very rich in phenolics, whose structures have been identified as curcuminoids. Phenolics are known to possess antioxidant properties. Free radical mediated damage to biological systems is recognized as the initiating agent for many diseases, such as cardiovascular diseases, cancer, and arthritis.

Turmeric and its constituents show beneficial effects on these diseases and on other illnesses. For example, the low incidence of large bowel cancers in Indians could be attributed to a high intake of natural antioxidants, such as curcumin in the diet. The anti-mutagenic and anti-tumor effects of curcumin are most widely studied. However, in recent years, it has been shown that the inhibition of arachidonic acid metabolism, modulation of cellular signal transduction pathways, inhibition of hormone, growth factor, and oncogene activity are some of the mechanisms by which curcumin causes tumor suppression. Chemopreventive activity of curcumin is observed when administered prior to, during, and after carcinogen treatment as well as when it is given only during the promotion/progression phase (starting late in premalignant stage) of colon carcinogenesis in F 344 rats.

Curcumin is also a powerftil inhibitor of the proliferation of several tumor cells, as well as an anti-inflammatory agent. It exhibits anti-clastogenic, anti-ftingal and anti-viral properties. However, the lack of information regarding the mechanisms of action of curcumin has precluded its clinical use in western countries. Several recent studies have given some insight into the molecular basis for the action of curcumin at the cellular level.

Curcumin is the main active ingredients in Turmeric. Curcumin is primarily used as a cholinergic and used to improve joint health. Curcumin synergizes particularly well with piperine, greatly increasing its bioavailability. Curcumin supplements can reduce age related memory loss by inhibiting the buildup of beta amyloid, a peptide commonly found in age related degenerative diseases of the brain. Curcumin Induces flow of bile which breaks down fat, keeps heart healthy by normalizing cholesterol level. Curcumin is helpful in digestive support and arthritis pain relief.

Curcumin (synonyms: turmeric yellow, kurkum, INS No. 100(i)) is an orange-yellow crystalline powder. Minor amounts of oils and resins naturally occurring in turmeric may be present.

The origin of the plant Curcuma longa L., which belongs to Zingiberaceae family is India. The plant is distributed throughout tropical and subtropical regions of the world, being widely cultivated in Southeast Asian countries. Turmeric, i.e., the ground rhizomes of Curcuma longa L., has a long history of use in food as a spice, mainly as an ingredient in many varieties of curry powders and sauces, where curcumin from turmeric is a main colouring substance.

The turmeric (Curcuma longa) plant, a perennial herb belonging to the ginger family, is cultivated extensively in south and southeast tropical Asia. The rhizome of this plant is also referred to as the root and is the most useful part of the plant for culinary and medicinal purposes. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice.

The characteristic yellow color of turmeric is due to the curcuminoids, first isolated by Vogel in 1842. Curcumin is an orange–yellow crystalline powder practically insoluble in water. The structure of curcumin (C 21 H 20 O 6) was first described in 1910 by Lampe and Milobedeska and shown to be diferuloylmethane. Turmeric is used as a dietary spice, coloring agent in foods and textiles, and a treatment for a wide variety of ailments. It is widely used in traditional Indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. Turmeric paste in slaked lime is a popular home remedy for the treatment of inflammation and wounds. For centuries, curcumin has been consumed as a dietary spice at doses up to 100 mg/d. Extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol.

Turmeric was described as C. longa by Linnaeus and its taxonomic position is as follows:

Class Liliopsida
Subclass Commelinids
Order Zingiberales
Family Zingiberaceae
Genus Curcuma
Species Curcuma longa

The wild turmeric is called C. aromatica and the domestic species is called C. longa. For the last few decades, extensive work has been done to establish the biological activities and pharmacological actions of turmeric and its extracts. Curcumin (diferuloylmethane), the main yellow bioactive component of turmeric has been shown to have a wide spectrum of biological actions. These include its anti-inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities.

Its anticancer effect is mainly mediated through induction of apoptosis. It’s anti-inflammatory, anticancer and antioxidant roles may be clinically exploited to control rheumatism, carcinogenesis and oxidative stress-related pathogenesis. Clinically, curcumin has already been used to reduce post-operative inflammation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, both turmeric and curcumin have the potential for the development of modern medicine for the treatment of various diseases.

Turmeric (Curcuma longa) is a native of Asia & India. The tuberous rhizone or underground steams of turmeric are used from antiquity as condiments. A dye and as an aromatic stimulants in several medicines. Turmeric is a very important spice in India, which produces nearly the whole world crop & uses 80% of it presently. It is cultivated in china, Taiwan, Indonesia, Sri Lanka, Australia, Africa, Peru & the West Indies. Turmeric uses dates back nearly 4000 years, to the vodic culture in India, when turmeric was the principal spice & also of religious significance. It is much reversed by thindus & associated with fertility. In to days India’s, turmeric still added to nearly every dish is it meat or vegetables. Turmeric has been used in Indian systems of medicine for a long time.

The turmeric has been used in herbal dating from about 600 BC and it also mentioned by Dioscorides. In Malaysia the paste of turmeric is spread on the mother’s abdomen and on the umbilical cord after child Birth. Not only to warm off one spirits, but also for its medicinal value. Bath the East & West have held its medicinal properties in high regards. Rhizomes are the used plant port. Fresh turmeric leaves are used in some regions of Indonesia as flavouring. The rootstick has aromatic & Spicy pogo once, which by drying gives way to a more medicinal Aroma. On storing, the smells rather quickly change to earthy and unpleasant. Similarly the colour of ground turmeric tends to fade if the spice is trolong. It is called Indian saffron because of its orange yellow colour. In language the name of turmeric just mean yellow root, English turmeric derived from the (Now absolute) French terremerite, probably because ground turmeric resembles mineral pigments (ochor),. The genus name Curcuma is of the same origin, being a latinization of Arabic Kurkum meaning saffron.

Distribution Turmeric (curcuma longa) is a native of Asia & India. The wild curcuma species, from which alonga evalved, is presumed to have attracted attention as on incidental source of food or because of its yellowish colour it night have acquired magical properties. Turmeric usage vedic culture in India. It is the most significance spice in India. In biblical times, it was used as a perfume as well as spice. In India it is used as medicine for a long time. It is listed in an Assyian herbal dating from about 600 BC. Turmeric is distributed in India specially in celebes. The Moluccas & Polynesia. This suggests an early cultural connection between the people of these areas of the indigenous per Aryan cultivates of India. It reaches China before the 7th century A. Du East Africa in 8th century A.D. & West Africa in the 13th century.

What is Turmeric?

Turmeric is a member of the Curcuma botanical group, which is part of the ginger family of herbs, the Zingiberaceae. The root and rhizome (underground stem) of the Curcuma longa L. plant is crushed and powdered into ground Turmeric. Ground Turmeric is used worldwide as a seasoning, the main ingredient in curry and as a source for Curcumin (Turmeric contains approximately 5% Curcumin) and its therapeutic effects.

What is Curcumin?

C21H20O6 Molecular chemical formula of Curcumin.

Curcumin is the main biologically active phytochemical compound of Turmeric. It is extracted and researched for its renowned range of health-related and disease-preventing medicinal properties.

What are some pharmacological properties and actions of Curcumin which have been and are currently being studied?

• Anti-cancer properties (Anticarcinogenic)
• Anti-arthritic
• Anti-inflammatory, relieves pain and inflammation (Antiphlogistic)
• Prevents blood clotting (Anticoagulant)
• Potent antioxidant properties
• Prevention of memory loss
• Prevention of Alzheimer’s disease
• Helps prevent oxidation of blood cholesterol (Antihypercholesterolemic)
• Lowers LDL (bad) cholesterol levels (Cholagogue)
• Increases HDL (good) cholesterol levels
• Antimutagenic action
• Antihepatotoxic action
• Chemoprotective agent
• Anti-excessive fluid (Antiedemic)
• Hepatoprotective action
• Protects against kidney injury
• Suppresses tumor growth (Antitumor)
• Helps protect against or lessen the degree of kidney lesions
• Antihypertensive
• Increases the production of digestive fluids and reduce gas (Carminative)
• Promotes excretion and removal of waste material (Depurative)
• Protects against free radical damage
• Neutralizing of free radicals
• Choleretic
• Anti-HIV, Inhibits Interleukin-1
• Antihyperlipemic / Hypolipidemic
• Antithrombotic activity
• Possesses antiviral, antimicrobial, and antiparasitic activity