PHARMACEUTICAL MANUFACTURING PLANT (ONCOLOGY DRUGS MANUFACTURING & PACKAGING, INJECTABLE DRUGS MANUFACTURING & PACKAGING, I.V. FLUIDS, TABLET, CAPSULES, SYRUPS, OINTMENTS ETC.)

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The foundation of the modern Indian pharmaceutical Industry was laid at the start of the current century when in 1901, a small factory known as the Bengal Chemical & Pharmaceutical works was established in Kolkata. Though the two world Wars gave a Phillip to the development of industry, the progress made under British rule was not significant except the British introduced into this country the allopathic system of medicine. The country depended largely for its requirements on U.K., France and Germany.

The development of Indian Drugs and pharmaceuticals Industry was not commonsurate with the size of this country and the growing needs of people, when Indian embarked on its planned economic expansion industry has been substantial and many sides with the result that it has becomes one of the leading industries. India is now producing a larger quantity of varied pharmaceuticals products.

Prior to the launching of the second plan the manufacture of pharmaceuticals was limited largely to the processing of bulk imported drugs into tablets, capsules and other formulations. Indian firms under agreement with foreign firms are making injectables, powders ointments and liquids, and were also filling antibiotics. Certain units were producing biological extracts, vacines, and syrup. Alkalods, like quinins stry-chinea, caffeine, and morphine were also being extracted. It was however obvious that the country could not forever be dependent on foreign manufacturers for both finished drugs and basis raw materials. With the changing political climate, pharmaceutical manufacturers in India were encouraged to take up the manufacture of basis drugs wherever it was economically possible and technically feasible.

A system of collaboration was instituted, under which Indian manufacturers in association with established firms in U.S.A., Italy, U.K. began to produce a fairly comprehensive range of basic items. While the allocation of foreign exchange for the import of raw materials and basic intermediates for the production of drugs, has been more or less static the value of products manufactured has increased progressively several fold clearly indicating the growing stature, of industry and its capacity to switching over to basic raw materials and components of indigenous origin, and now the country is stated to achieve self, sufficiency in synthetic drugs of the sulpha group, anti T.B. drugs, Vitamins, and intermediates.

It has, however, been found that the present installed capacity is insufficient to meet the over growing demand of the massive population and the scope for new units to come up is substantial.

Intra venous fluids, in general are used as I.V drips for patients in nursing homes and hospitals suffering from acute dehydration or considerable debilitating conditions. These I.V fluids replanish the body fluids. Though a number of I.V fluids are there, generally three types of I.V fluids are used in hospitals as I.V drips. They are as follows:-

1. Dextrose injection fluid

2. Dextrose and sodium chloride injection fluid

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Description

INTRODUCTION
PARENTAL PRODUCTS (INJECTABLES)
INJECTION
ARSENIC
MODE OF ADMINISTRATION OF INJECTABLES
EYE DROPS
OXYTOCIN INJECTION (PITUITARY)
PROPERTIES & CHARACTERISTICS OF INJECTION (DISTILLED WATER)
CHARACTERISTICS OF INJECTABLES
PROPERTIES OF OPHTHALMIC PREPARATION
(EYE DROPS)
1. STERILITY
2. TONOMICITY
SURFACE ACTIVITY
CLARITY
VISCOSITY
OXYTOCIN INJECTION (PITUITARY)
USES AND APPLICATIONS
ADVANTAGES OF PARENTERAL PRODUCTS (INJECTABLES)
OXYTOCIN INJECTION (PITUITARY)
B.I.S. SPECIFICATION
RAW MATERIALS FOR INJECTION DISTILLED WATER
GLASS AMPOULES
TYPES OF I.V. FLUID
COMMONLY USED I.V. FLUIDS
HOW INTRAVENOUS FLUIDS ARE CREATED
DEXTROSE SALINE INJECTION
MARKET SURVEY
MARKET SIZE
MARKET STRUCTURE
INVESTMENTS
GOVERNMENT INITIATIVES
ROAD AHEAD
INCREASING INVESTMENTS IN THE SECTOR
DETAILED EXPORT DATA OF PHARMA PRODUCT PHARMACEUTICAL
OVERVIEW OF THE INTRAVENOUS SOLUTIONS MARKET
GEOGRAPHICAL SEGMENTATION OF THE INTRAVENOUS SOLUTIONS
MARKET
COMPETITIVE LANDSCAPE AND KEY VENDORS
KEY VENDORS IN THIS MARKET ARE –
GROWTH DRIVERS, CHALLENGES, AND UPCOMING TRENDS HOME TREATMENT
ONCOLOGY DRUG MARKET IN INDIA
FINDINGS FROM A STUDY CONCLUDED THE CANCER SCENARIO
IN INDIA THAT
MARKET SIZE
STRENGTHS
WEAKNESS
OPPORTUNITIES
MARKET DRIVERS
INDUSTRY CHALLENGES
GLOBAL CANCER DRUGS MARKET
ONCOLOGY- A BOOMING BUSINESS
LATEST DEVELOPMENTS IN INDIAN ONCOLOGY SPACE
NEW ENTRANTS IN THE INDIAN ONCOLOGY MARKET
MANUFACTURER OF PHARMACEUTICAL PRODUCTS
GLOBAL ONCOLOGY MARKET AND PROCESS SOLUTION
ONCOLOGY AND ITS TREATMENT
CHEMOTHERAPY
GENERIC DRUGS IN ONCLOGY
USES AND APPLICATION OF I.V. FLUIDS
MANUFACTURING PROCESS OF INJECTION WATER
FILLING OF AMPOULES
PROCESS FLOW CHART
PROCESSING OF PARENTRAL PRODUCTS INJECTIONS
TECHNIQUES INVOLVED IN THE PREPARATION OF INJECTABLES
PACKING OF PARENTERAL PRODUCTS (PACKING OF INJECTABLES)
PROCESSING OF CONTAINES & CLOSURES
EVALUATION OF PARENTERAL PRODUCTS
A. STERILITY TEST
PYROGEN TEST
CLARITY TESTS
LEAKAGE TESTS
FLOW DIAGRAM FOR PREPARATION OF INJECTABLES
PREPRATION OF EYE DROPS
FLOW DIAGRAM FOR PREPARATION OF EYE DROPS
MANUFACTURING PROCESS FOR OXYTOCIN INJECTION (PITUITARY)
THEORY 93
RAW MATERIAL REQUIRED
MANUFACTURING PROCESS
PROCESS FLOW SHEET FOR OXYTOCIN INJECTION (PITUITARY)
FORMULATIONS OF TABLETS 95
1. TABLETS FOR FATIGUE & GENERAL TONIC
2. ANTI ASTHMATIC
3. COLCHICINE TABLETS
4. TABLETS FOR INFLUENZA AND COMMON COLD
5. ANTI ALLERGIC TABLETS
6. MULTI VITAMIN TABLETS, 500 MG EACH TABLET CONTAINS
7. ENTERO VIOFORM TABLETS
8. TABLETS FOR COMMON COLD
9. TABLETS FOR MENOAPUSE SYNDROMS
10. STIMULATING TABLETS
11. ANACIN TABLETS
12. IRON TABLETS
13. CAPSULES
14. ANTI INFLAMMATORY ANTIPYRETIC AND ANALYGERIC
15. BROAD SPECTRUM ANIT-BIOTIC CASPULES
16. IRON WITH VITAMIN CAPSULES
17. ANTI ANNEMIA CAPSULES
18. CHLORAMPHENICOL CAPSULES
19. HEAMATINIC CAPSULES
20. UROBIOTIC CAPSULES
INJECTIONS FORMULATIONS
TERRAMYCIN 1 M
AMPICILLIN INJECTION
SULPHACETAMIDE EYE-DROP
SULPHACETAMIDE EYE-DROP EACH ML CONTAINS
BETENSOL-N-EYE/EAR DROPS CONTAINS
SALIENT FEATURES OF FORMULATIONS OF DPHTHALMIC PREPARATIONS
OXYTOCIN INJECTION
OXYTOCIN -B VETC
MANUFACTURING PROCESS OF INJECTIONS
FILLING OF AMPOULES
FORMULATIONS OF SYRUPS
SYRUPS
ANTI ALLERGIC COUGH SYRUP
EDIATRIC SYRUP OF PARACETAMOL
VICKS FORMULA 44 COUGH MIXTURE
PARACETAMOL – VITAMINIC SYRUP
MULTIVITIMAN SYRUP
COUGH SYRUP
1. GENERAL TONIC (MULTI VITAMIN)
2. SODIUM GLYCEROPHOSPHATE 40 MG
3. VITAMIN B COMPLEX WITH DIGESTIVE ENZYMES
TONIC LIQUID
PALATABLE POTASSIUM SUPPLEMENT
LOTION
1. EYE LOTION
2. SKIN LOTION (FOR SPOT & PIMPLES)
3. ANTI ALLERGIC LOTION (CALAMINE LOTION)
TERRAMYCIN DENTAL PASTE
BEPARINE CREAM
ANTISEPTIC CREAM
ANTI FUNGAL SKIN OINTMENT
BURNOL OINTMENT
FORMULATION OF OINTMENT BASES
WASHABLE OINTMENT BASE (USED AS SCALP OINTMENT BASE)
GREASE LESS BASE (USED IN MAKING SKIN OINTMENT)
MANUFACTURING PROCESS OF TABLETS
FLOW DIAGRAM OF TABLET MAKING PLANT
MANUFACTURING PROCESS OF LIQUIDS (SYRUP)
FILTERATION
BOTTLING
FLOW DIAGRAM OF MIXING PLANT
CAPSULE FILLING AND SEALING
FILLING
SEALING AND LOCKING
FLOW DIAGRAM OF CAPSULE MAKING PLANT
MANUFACTURE OF LOTION
FLOW DIAGRAM OF LOTION MAKING PLANT
OINTMENT AND PASTE MAKING
FORMULATION
MELTING
MIXING
FILLING
MACHINERY REQUIRED
FLOW DIAGRAM FOR PASTE & OINTMENT MAKING
DEXTRAN 110 INJECTIONS
SODIUM CHLORIDE AND DEXTROSE INJECTION
BASIC RAW MATERIALS
COMPOSITION OF I.V. FLUID
COMPOSITION OF COMMON I.V. FLUID (MEQ/L)
COMPOSITION OF I.V. FLUIDS
COMPOSITION OF COMMERCIAL I.V. FLUID AVAILABLE
MANUFACTURING PROCESS OF I.V. FLUID (FFS TECHNOLOGY)
PROCESS FLOW DIAGRAM
FORM FILL SEAL TECHNOLOGY
1. FORM-FILL-SEAL TECHNOLOGY
1.5 FILTRATION (MEMBRANE)
PROCESS IN DETAILS OF I.V. FLUID
1. DISTILLED WATER PREPARATION
2. SOLUTION PREPARATION
3. INJECTION BLOW MOULDING
4. MOULDING PROCESS
5. FILLING PROCESS
6. SEALING PROCESS
7. MOULD OPENING PROCESS
FILTRATION AND FILLING
STERILIZATION
FLOW DIAGRAM OF MANUFACTURING OF I.V. FLUIDS
ONCLOGY DRUGS
FORMULATION OF LETROZOLE TABLETS
FORMULATION OF ENZOLUTAMIDE CAPSULE
FORMULATION OF TEMOZOLOMIDE CAPSULE
PLANT LAYOUT
SUPPLIERS OF PLANT AND MACHINERY FOR I.V. FLUID
SUPPLIERS OF PHARMACEUTICAL PLANTS MACHINERY
SUPPLIERS OF RAW MATERIALS
GELATINE
FOOD COLOURS
SODIUM SULPHATE
PINE OIL
GLYCERINE
CAUSTIC SODA
METHYLATED SPIRIT
ASPIRIN
PARACETAMOL TABLETS (PCM)
PAPAIN POWDER
VITAMIN
THYMOL

APPENDIX – A:

1. COST OF PLANT ECONOMICS
2. LAND & BUILDING
3. PLANT AND MACHINERY
4. FIXED CAPITAL INVESTMENT
5. RAW MATERIAL
6. SALARY AND WAGES
7. UTILITIES AND OVERHEADS
8. TOTAL WORKING CAPITAL
9. COST OF PRODUCTION
10. PROFITABILITY ANALYSIS
11. BREAK EVEN POINT
12. RESOURCES OF FINANCE
13. INTEREST CHART
14. DEPRECIATION CHART
15. CASH FLOW STATEMENT
16. PROJECTED BALANCE SHEET

Additional information

Plant Capacity

PHARMACEUTICAL MANUFACTURING PLANT
Land and Building

(20000 Sq.Mtr)
Plant & Machinery

US$. 2742857
Rate of Return

66%
Break Even Point

30%

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