NICOTINE BASED PRODUCTS (NICOTINE ALKALOID 95%, NICOTINE USP/EP, NICOTINE POLACRILEX, NICOTINE BITARTRATE DIHYDRATE)

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From harvesting of tobacco to manufacture of products, large quantities of waste materials comprising rejected leaves broken bits of lamina nidribs, stalks and stems accumulate such materials however can be utilized with considerable benefit. Nicotine and tobacco seeds are by far the most important by products derived from tobacco waste.

In addition many other chemicals like nicotine acid, nicotine sulphate, rutin, pectic and certain organic acids can be produced from these wastes.

The average nicotine content in Indian tobacco waste is 1-3% waste containing even less than 2 percent nicotine can be utilized. A simple and economic process by which about 95% of the nicotine present in tobacco waste can be recovered as nicotine sulphate has been developed by National Chemical Laboratory, Poona, and is being commercially exploited by Tobacco By Products Ltd., Guntur Urvakunj Tobacco by Products, Dharmaj (Gujarat) is also one of the nicotine sulphate manufacturing units.

Nicotine sulphate is extensively used in the control of insect pest of agricultural importance. It is being manufactured from waste tobacco and from the liquors obtained from factories making chewing and smoking tobacco. The waste tobacco is macerated with water and lime and then steam distilled. The distillate is neutralized with sulphuric acid and concentrated.

TOBACCO INDUSTRY AND EXPORT

Tobacco in India was introduced by Portuguese in the 17th century, is appreciated worldwide for its rich, full-bodied flavour and smoothness. It is now an increasingly well-known and respected commodity in global tobacco markets and has found its way into cigarettes manufactured in several countries. India has an impressive and progressive profile in the global tobacco industry, and it is an important commercial crop grown here. India is the second-largest tobacco producer and exporter in the world.

Tobacco Exports from India and Key Markets

• The tobacco export in the month of August 2021 was US$ 72.28 million and the total export during April 2021 to August 2021 was 386.08 million.

• The tobacco export in the month of March 2021 was US$ 85.52 million and the total export during FY21 was US$ 875.09 million.

• In FY21, export of unmanufactured tobacco stood at US$ 517.54 million.

• The total export of flue-cured Virginia (FCV) tobacco in July 2021, was US$ 18.7 million, while for a period from April 2021 to July 2021, it was US$ 139.6 million.

• India export unmanufactured tobacco primarily to Belgium, Korea, Nigeria, Egypt and Nepal. Western Europe is a key market for Indian tobacco export.

Foreign Direct Investment in Tobacco Industry in India

In August 2020, the parliamentary panel proposed permitting regulated foreign direct investment in India’s tobacco production and cigarette manufacturing to stimulate agricultural exports.

The panel proposed establishment of tobacco farms dedicated to exports only to improve outward shipments and to provide benefits to farmers. It also suggested to provide export incentives for tobacco and tobacco products.

Tobacco Board

The Tobacco Board of India is a facilitator for tobacco growers, traders and exporters. By creating synergies between these stakeholders, the Board fosters a vibrant enterprise, with a deep social conscience and strong national commitment. The Board estimates demand and regulates the production of FCV tobacco to match demand to ensure a fair price for the produce. It assists tobacco farmers in securing crop loans, quality seeds, fertilisers and other critical inputs, and also counsel’s farmers on GAP to produce quality tobaccos to meet the evolving international demand. In addition, the Board conducts auction for the sale of tobacco in a competitive and transparent environment. On the export front, the Board strives to improve the existing markets and develop new markets for Indian tobacco and tobacco products by undertaking brand building exercises and participation in international tobacco exhibitions.

TOBACCO IN INDIAN ECONOMY

Tobacco is one of the most economically significant agricultural crops in the world. It is a drought tolerant, hardy and short duration crop which can be grown on soils where other crops cannot be cultivated profitably. In India, Tobacco crop is grown in an area of 0.45 M ha (0.27% of the net cultivated area) producing ~ 750 M kg of tobacco leaf. India is the 2nd largest producer and exporter after China and Brazil respectively. The production of flue-cured Virginia (FCV) tobacco is about 300 million kg from an area of 0.20 M ha while 450 M kg non-FCV tobacco is produced from an area of 0.25 M ha. In the global scenario, Indian tobacco accounts for 10% of the area and 9% of the total production.

Unique feature of tobacco production in India is that varied styles of Flue-cured Virginia (FCV) and different types of non-FCV tobacco are produced under diverse agro-ecological situations spread all over the country. About 15 states in the country grow tobacco, significantly influencing the economy and prosperity of the farming community. FCV, Bidi, Hookah, Chewing, Cigar-wrapper, Cheroot, Burley, Oriental, HDBRG, Lanka, Pikka, Natu, Motihari, Jati etc. are the different types of tobacco grown in the country. FCV, Burley and Oriental tobacco are the major exportable types.

Tobacco provides livelihood security to 36 million people including 6 million farmers and 20 million farm labour engaged in tobacco farming besides 10 million people working in processing, manufacturing and exports, in India. Bidi rolling alone provides employment to 4.4 million people and 2.2 million tribals are involved in tendu leaf collection. The main beneficiaries are the small and marginal farmers, rural women, tribal youth and weaker sections of the society. Annually, tobacco contributes ` 4,400/- crores towards foreign exchange earnings accounting for 4% of the country’s total agri-exports and ` 14,000 crores to excise revenue which is more than 10% of the total excise revenue collection from all sources.

India enjoys an edge over the leading tobacco producing countries in terms of low production cost, average farm and export prices. Thus, Indian tobacco is considered as ‘value for money’. India is one of the leading exporters of tobacco and occupies second place after Brazil. The country accounts for 6% by volume and 0.7% by value of the world tobacco trade and 80-85% of our exports continue to be FCV alone. During the past five years, exports of tobacco and tobacco products increased by 76% and 209% in quantity and value terms, respectively. UK, Germany, Belgium, the erstwhile USSR, South Korea and South Africa are the major importers of Indian FCV tobacco accounting for more than 60% of our exports. At present, Brazil, Zimbabwe, Turkey, China and Indonesia are the competitors to India in the export market. India’s share in the world cigarette exports is less than 1% only. However, the exports of scented Bidis, Hookah tobacco paste, scented chewing tobacco and Zarda are noteworthy and there is a scope for augmenting the exports of these products in the near future.

POSITIVE FEATURES OF INDIAN TOBACCO

The distinctive and positive features of Indian tobacco include the lower levels of heavy metals, very low levels of Tobacco Specific Nitrosamines (TSNAs) and pesticide residues compared to the other tobacco producing countries in the world. Further, endowed with varied agro-climatic conditions, India has the capacity to produce different styles of tobacco ranging from coloury neutral filler to flavourful leaf catering to the needs of a wide variety of customers globally. In addition, production and processing costs of tobacco are also quite low in India, thus making the Indian tobacco price-competitive and value for money.

IMPACT OF TOBACCO RESEARCH

Sustained research and developmental efforts by the scientists of CTRI have resulted in evolving 90 high yielding varieties (HYV) and appropriate agro-technologies, which have made a significant impact on tobacco production, marketing and export earnings. As a result of adoption of HYV and proven production and protection technologies, there has been a quantum jump in the average productivity levels in FCV and non-FCV tobacco types.

Improvement in physical and chemical quality attributes of the tobacco leaf including lower levels of harmful constituents like TSNA, tar etc. has made the place of Indian tobacco secure in the international market as ‘quality filler’. Significant reduction in cost of production achieved through the adoption of HYV and improved crop management strategies gave a competitive edge to Indian tobacco in the international market.

Adoption of recommended IPM strategies for pest management has considerably brought down the pesticide residue levels much below the International Guidance Residue Levels (GRLs), thus enhancing the acceptability and saleability of our tobacco in the international market. Refined fertilizer management practices developed and propagated by the Institute involving Integrated Nutrient Management (INM), withdrawal of potash application in northern and central black soils and reducing the phosphorus dose in NBS, NLS and KLS have contributed to considerable saving in foreign exchange and conserving soil health. The micro-irrigation and fertigation systems have resulted in considerable saving in water and nutrients thereby preventing percolation and leaching losses.

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Description

INTRODUCTION
TOBACCO INDUSTRY AND EXPORT
TOBACCO EXPORTS FROM INDIA AND KEY MARKETS
FOREIGN DIRECT INVESTMENT IN TOBACCO INDUSTRY IN INDIA
TOBACCO BOARD
TOBACCO IN INDIAN ECONOMY
POSITIVE FEATURES OF INDIAN TOBACCO
IMPACT OF TOBACCO RESEARCH
USES AND APPLICATION OF NICOTINE BITARTRATE DIHYDRATE
USES AND APPLICATIONS OF NICOTINE SULPHATE
PROPERTIES OF NICOTINE SULPHATE
HAZARD AND SHIPPING REGULATION:-
APPLICATION OF NICOTINE POLACRILEX
ADVANTAGE OF NICOTINE POLACRILEX
NICOTINE POLACRILEX/RESINATE USP/EP 20%
NICOTINE POLACRILEX/RESINATE USP/EP 15%
B.I.S. SPECIFICATION
1. SCOPE
2. REQUIREMENTS
3. PACKING AND MARKING
4. SAMPLING
5. TESTS
APPENDIX -A
DETERMINATION OF NICOTINE CONTENT
A – 1 METHOD
A – 2 REAGENTS
APPENDIX – B
SEDIMENTATION TEST
B – 1 PROCEDURE
B – 2 REPORT
NICOTINE SULPHATE 40%
SPECIFICATION
CHEMICAL COMPOSITION:
MODE OF ACTION:
USES:
CHEMICAL FORMULA:
ADVANTAGES:
NICOTINE SULPHATE 40%
USES AND APPLICATION OF NICOTINE ALKALOID 95%
NICOTINE ALKALOID 95%
SPECIFICATIONS
OTHER INFORMATION
PROPERTIES OF NICOTINE POLACRILEX 20%
PRODUCT SPECIFICATION:
COMPOSITION:
MARKET OVERVIEW OF TOBACCO
MARKET OVERVIEWOF NICOTINE AND NICOTINE PRODUCTS IN INDIA
PRODUCTS FROM TOBACCO AND TOBACCO WASTES:
NICOTINE/NICOTINE DERIVATIVES FROM TOBACCO:
NICOTINE AND ITS COMMERCIALLY IMPORTANT DERIVATIVES:
WORLD PESTICIDE MARKET AND PROSPECTS FOR NICOTINE SULPHATE
STATUS OF TOBACCO WASTE BASED INDUSTRIES IN INDIA
OVERVIEW OF TECHNOLOGIES FOR NICOTINE BASED PRODUCTS
NEED FOR DEVELOPMENT OF ALTERNATE USE FOR TOBACCO:
[COMMERCIALLY IMPORTANT APPLICATIONS]:
A LOOK AT THE ORGANS OF THE BODY HARMED BY TOBACCO SMOKE
PHARMACEUTICAL USE OF NICOTINE:
COMMERCIAL ASPECTS OF NICOTINE SULPHATE & NICOTINE DERIVATIVES
CONCLUSIONS AND RECOMMENDATIONS:
RECOMMENDATIONS:
MARKET OVERVIEW OF NICOTINE GUMS
PRESENT MANUFACTURERS/SUPPLIERS OF NICOTINE BASED PRODUCTS
CHEMICAL COMPOSITION OF TOBACCO
CHEMISTRY OF NICOTINE
THE DISTILLATION AND CONCENTRATION INSTALLATION WAS BUILTUP AS FOLLOWS:-
(1) THE STEAM DISTILLATION KETTLE.
(2) THE STEAM-HEATED NICOTINE CONCENTRATION CHAMBER.
(3) THE NICOTINE CONCENTRATIOIN FLASKS.
(D) THE DISTILLATION AND CONCENTRATION PROCESS.
(1) THE CONCENTRATION OF THE ACID IN THE FLASKS.
(2) THE TEMPERATURE OF THE CONCENTRATION CHAMBER
(3) THE DLSTILLATION PERIOD.
(4) THE AMMONIUNN SULPHATE FORMED IN ‘THE RECEIVING FLASKS.
(5) THE SEPARATION OF THE AMMONIUM SULPHATE AND NECOTINESULPHATE
VALUE OF BY PRODUCTS
THE EXTRACTED TOBACCO RESIDUE
COMMERCIAL
CHARACTERISTICS & APPLICATION OF NICOTINE:-
MODE ACTION:-
ZONES OF CULTIVATION OF TOBACCO:-
RAW MATERIALS
TOBACCO:-
CULTIVATION
SOWING AND GROWTH
HARVEST
GLOBAL PRODUCTION
TRENDS
MAJOR PRODUCERS
UNITED STATES
CHINA
BRAZIL
INDIA
BENZENE:-
HAZARD:-
LIME:-
HAZARD:-
SULFURIC ACID:-
HAZARD:-
TOBACCO LEAF BY-PRODUCTS (TOBACCO WASTE)
MANUFACTURING PROCESS OF NICOTINE USP/EP
MASS BALANCE PER BATCH
MASS BALANCE PER MONTH
MASS BALANCE PER MONTHSFOR NICOTINE USP/EP
MANUFACTURING PROCESS OF NICOTINE POLACRILEX (USP/EP)
MASS BALANCE PER BATCH
NO OF BATCH: 8.3 PER MONTH
MASS BALANCE PER BATCH
MASS BALANCE PER MONTHSFOR NICOTINE POLACRILEX USP/EP
MANUFACTURING PROCESS OF NICOTINE BITARTRATE DIHYDRATE
CHEMICAL REACTION
MASS BALANCE PER MONTH
MASS BALANCE PER MONTHSFOR NICOTINE BITARTRATE DIHYDRATE
MANUFACTURING PROCESS OF NICOTINE 95%
MASS BALANCE PER BATCH
MASS BALANCE PER MONTH
MANUFACTURING PROCESS NICOTINE SULPHATE (40%)
PROCESS DETAILS OF NICOTINE (USP)
PROCESS FLOW DIAGRAM
PROCESS FLOW SHEET FOR NICOTINE SULPHATE FROM TOBACCO WASTE
PROCESS FLOW DIAGRAM FOR NICOTINE
PROCESS FLOW DIAGRAM FOR NICOTINE POLACRLEX
PROCESS FLOW DIAGRAM FOR NICOTINE DITARTRATE DIHYDRATE
IMPLEMENTATION SCHEDULE:-
MATERIAL SAFETY DATA SHEET OF NICOTINE SULPHATE 40%
TESTING METHOD OF NICOTINE AND NICOTINE SULPHATE
EXAMPLE L
STAGE 1 HARVESTING AND DEEP FREEZING
STAGE II MIXING AND PERCOLATION
STAGE III EXTRACTION
STAGE IV SEPARATION
STAGE V FILTRATION AND PURIFICATION
STAGE VI TESTING
STAGE VII PACKING
EXAMPLE 2
STAGE 1 MIXING
STAGE II PERCOLATION
STAGE III EXTRACTION
STAGE IV SEPARATION
STAGE V FILTRATION AND PURIFICATION
STAGE VI PACKING
STAGE VII ALKALIZATION
STAGE VIII PURIFICATION OF NICOTINE ALKALOID
STAGE IX DISTILLATION OF NICOTINE ALKALOID
STAGE X TESTING
STAGE XI PACKING
EXAMPLE 3
STAGE 1 MIXING
STAGE II MIXING AND PERCOLATION
STAGE III EXTRACTION
STAGE IV SEPARATION
STAGE V FILTRATION AND PURIFICATION
STAGE VI PACKING
STAGE VIII PURIFICATION OF NICOTINE ALKALOID
STAGE IX DISTILLATION OF NICOTINE ALKALOID
STAGE X TESTING.
STAGE XI PACKING
EXAMPLE 4
STAGE 1 MIXING
STAGE II PERCOLATION
STAGE III EXTRACTION
STAGE IV SEPARATION
STAGE V FILTRATION AND PURIFICATION
STAGE VI PACKING
STAGE VII ALKALIZATION
STAGE VIII PURIFICATION OF NICOTINE ALKALOID
STAGE IX DISTILLATION OF NICOTINE ALKALOID
STAGE X TESTING
STAGE XI PACKING
EXAMPLE 5
STAGE I WASHINGS OF THE INSOLUBLE FRACTION
STAGE II CENTRIFUGATION AND DRYING OF INSOLUBLE FRACTION
STAGE III CENTRIFUGATION AND DRYING OF INSOLUBLE FRACTION
STAGE IV RECONSTITUTION OF THE TOBACCO BY IMPREGNATION
STAGE V TESTING OF THE TOBACCO
STAGE VI PACLDNG
TECHNOLOGY SUPPLIERS FOR NICOTINE BASED PRODUCTS
SUPPLIERS OF RAW MATERIALS
SUPPLIERS OF TOBACCO WASTE
SUPPLIERS OF BENZENE
SUPPLIERS OF LIME POWDER
SUPPLIERS OF PLANT & MACHINERY
SUPPLIERS OF REACTION VESSEL
SUPPLIERS OF INDUSTRIAL FILTERS
SUPPLIERS OF DISTILLATION UNITS
SUPPLIERS OF EVAPORATORS
SUPPLIERS OF TRAY DRYER
SUPPLIERS OF DIGESTER TANKS
SUPPLIERS OF CRYSTALLIZATION TRAY
SUPPLIERS OF CENTRIFUGE MACHINE
SUPPLIERS OF STORAGE TANK
SUPPLIERS OF WATER SOFTENING PLANT
SUPPLIERS OF STEAM BOILERS
SUPPLIERS OF GENERATOR (D.G. SET)
SUPPLIERS OF PACKING MACHINE
SUPPLIERS OF CONVEYOR BELT
SUPPLIERS OF ELEVATORS, ESCALATORS

APPENDIX – A:

01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)

Additional information

Plant Capacity

1.72 MT/Day

Land & Building

(5000 sq.mt.)

Plant & Machinery

US$ 464285

Rate of Return

64%

Break Even Point

25%